Δοσολογία του κολύριου Tobrex 0,3%.

[Argirios Argiriou]

TOBREX EY.DRO.SOL 0,3% BTx1 FLx5ML

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NDICATIONS AND USAGE:

Tobramycin Ophthalmic Solution USP, 0.3% is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of Tobramycin Ophthalmic Solution USP, 0.3%. Clinical studies have shown tobramycin to be safe and effective for use in pediatric patients.

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DOSAGE AND ADMINISTRATION:

In mild to moderate disease, instill one or two drops into the affected eye(s) every four hours. In severe infections, instill two drops into the eye(s) hourly until improvement, following which treatment should be reduced prior to discontinuation.


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[Argirios Argiriou]

Ένα συνώνυμο κολλύριο του Tobrex 0,3% είναι το Eyetobrin 0,3% της Cooper S.A.

Στις 22/04/2025 που το έψαξα το Tobrex ήταν σε σχετική έλλειψη ενώ το Eyetobrin κυκλοφορούσα κανονικά. Το eyetobrin υπάρχει μόνο σε μία μορφή.

[Argirios Argiriou]

May 22, 2025, Journal Watch.

Bacteria and Viruses That Cause Conjunctivitis in Children

Clement D. Lee, MD, MSc, reviewing Frost HM et al. J Pediatr 2025 Jan

Of 52 pathogens, only H. influenzae was associated with acute infectious conjunctivitis.

Most conjunctivitis in children is attributed to bacterial infection and is managed with topical antibiotics (JAMA 2022; 327:2231). To update the epidemiology of this condition, researchers enrolled 194 children with acute infectious conjunctivitis at two health systems in Colorado and Wisconsin from 2019 through 2023; they also enrolled 196 age-matched controls who either were healthy or had upper respiratory illnesses without conjunctivitis. Conjunctival swabs were collected and tested for 52 bacteria and viruses via PCR testing.

Bacteria were isolated in 76% of children with conjunctivitis, 58% of healthy controls, and 56% of controls with upper respiratory illnesses; however, only Haemophilus influenzae was associated significantly with conjunctivitis. Clinical features associated with H. influenzae included purulence, rhinorrhea and congestion, cough, and young age. Antibiotics were prescribed to most children with conjunctivitis (54%), but fewer than half of parents understood directions for administration. Antibiotic use was not associated with symptom improvement or resolution by day 5, decreased need for follow-up care, or fewer missed days of childcare or school. Twenty percent of children who received topical antibiotics experienced adverse events.

Comment

H. influenzae was the only treatable bacterium associated with conjunctivitis in this study, so theoretically it should be the main target of antibiotics, if any are prescribed. This study also should compel clinicians to review antibiotic instructions meticulously with parents and to counsel them about adverse events (e.g., stinging, decreased vision, ocular hyperemia). Withholding antibiotics and monitoring also might be reasonable, because many cases are self-limited, although clinicians should also factor in parental preferences and daycare stipulations.

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